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Kashi Clinical Laboratories
10101 SW Barbur Blvd, Suite 200
Portland, OR 97219

1 877 879-1815
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Thank you for your interest in Kashi Health's genetic testing services.

Our genetic tests require guidance from a licensed healthcare provider. You may find a qualified provider from our list of approved professionals in the link below, or you may email your provider directly requesting that they contact us to request a genetic test. We wish you the best in your pursuit of healthy living.

1-877-879-1815

Birdshot Chorioretinopathy

Birdshot Chorioretinopathy is a rare form of bilateral posterior uveitis, accounting for between 1 – 3% of all uveitis cases. A slight female predominance has been reported. The disease is uncommon in children.

Birdshot Chorioretinopathy causes severe, progressive inflammation of both the choroid and the retina. The name of the disease stems from the hypopigmentation pattern of the lesion on the retina, which resembles the impacts from a shotgun. Symptoms of Birdshot Chorioretinopathy include retinal vasculitis, particulate matter in the vitreous or vitreous inflammation, macular edema, flashing lights in the eyes, night blindness and loss of color vision. A frequent prognosis is complete loss of visual acuity.

Clinical Utility:

Birdshot Chorioretinopathy has the strongest association to the HLA-A*29 antigen. More than 95% of patients carry the HLA-A*29 antigen with the relative risk of HLA-A*29 carriers developing Birdshot Chorioretinopathy being estimated at between 50 and 250. The mechanism by which HLA-A*29 confers susceptibility to Birdshot Chorioretinopathy is unknown. Proposals include antigen specific molecular mimicry following an infection or a role for retinal S-Antigen.

The presence of HLA-A*29 alone is not sufficient for a diagnosis of Birdshot Chorioretinopathy, as there are many cases of patients who do not carry HLA-A*29. Nonetheless the strong association suggests that genetic testing for HLA-A*29 is useful as a supportive finding as part of the diagnosis.

Method:

Kashi Clinical Laboratories utilizes a combination of PCR-SSO (polymerase chain reaction sequence specific oligonucleotide typing) and SBT (sequence based typing) for testing.

What is the Next Step? 

Make Kashi Health's Genetic Testing part of your patient's treatment plan today. 

Questions? Please contact our customer service team at 877-879-1815 or 503-206-4989 or by email at This email address is being protected from spambots. You need JavaScript enabled to view it. . We are available Monday through Friday, from 8:00 AM - 5:00 PM, Pacific Time.

 References
  1. LeHoang P et al. HLA-A29.2 subtype associated with birdshot retinochoroidopathy. Am J Ophthalmol. 1992; 113:33.
  2. Rosenbaum JT. Acute anterior uveitis and spondyloarthropathies. Rheum Dis Clin North Am. 1992; 18:143.
  3. Lyons JL et al. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol. 1997; 115:61.