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Kashi Clinical Laboratories
10101 SW Barbur Blvd, Suite 200
Portland, OR 97219

1 877 879-1815
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Thank you for your interest in Kashi Health's genetic testing services.

Our genetic tests require guidance from a licensed healthcare provider. You may find a qualified provider from our list of approved professionals in the link below, or you may email your provider directly requesting that they contact us to request a genetic test. We wish you the best in your pursuit of healthy living.

1-877-879-1815

Multiple Sclerosis

Multiple sclerosis (MS) is an idiopathic autoimmune neurodegenerative disease in which dysregulation of the immune system causes myelin sheath degradation. Multiple sclerosis is characterised by plaques or lesions in the brain and spinal cord.

The location and size of the lesions is unpredictable. Symptoms of Multiple Sclerosis include affected coordination, balance and vision, and disturbances in the bowel, bladder and sexual organs. Disease onset is typically between the ages of 20 and 40. Women have a 2 -3 fold higher incidence of MS than men. The distribution of MS inversely parallels the global distribution of UV light, suggesting a role for vitamin D in the disease.

Clinical Utility:

The main value of genetic testing in MS is to provide insights into the mechanism of the disease, thereby potentially suggesting strategies for prevention and treatment, rather than as a diagnostic tool.

First degree relatives of patients with MS are generally at 20 – 40 times greater risk of developing the disease themselves, compared to the general population, showing that the disease has a large genetic component. HLA-DRB1*15:01 is a disease susceptibility gene, accounting for up to 35% of the heritability of the disease. Homozygosity for this haplotype increases disease risk six fold. The exact mechanism by which HLA increases the susceptibility to MS is unknown. A recent finding of a vitamin D response element in the promoter region of HLA-DRB1, which is completely conserved in HLA-DRB1*15:01, together with evidence showing that vitamin D is significantly lower in MS patients is suggestive of combined effects of HLA-DR15:01 inheritance and vitamin D exposure on MS risk.

Method:

Kashi Clinical Laboratories utilizes a combination of PCR-SSO (polymerase chain reaction sequence specific oligonucleotide typing) and SBT (sequence based typing) for testing.

Kashi's in-house laboratory and experienced health professionals ensure that customer service is personal, timely, and tailored to every patient's needs.

What is the Next Step? 

Make Kashi Health's Genetic Testing part of your patient's treatment plan today. 

Questions? Please contact our customer service team at 877-879-1815 or 503-206-4989 or by email at This email address is being protected from spambots. You need JavaScript enabled to view it. . We are available Monday through Friday, from 8:00 AM - 5:00 PM, Pacific Time.

 References
  1. Banwell BL. Pediatric multiple sclerosis. Curr Neurol Neurosci Rep. 2004; 4:245.
  2. Friese MA et al. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med. 2008; 14:1227.
  3. Lincoln MR et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet. 2005; 37:1108.
  4. Nolan D et al. Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk. Neurology. 2012; 79:538.
  5. Ramagopalan SV et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 2009; 5:e1000369.
  6. Renoux C et al. Natural history of multiple sclerosis with childhood onset. N Engl J Med. 2007; 356:2603.