kashi-health-logo

Kashi Clinical Laboratories
10101 SW Barbur Blvd, Suite 200
Portland, OR 97219

1 877 879-1815
1000 characters left

Contact Information

Other Information

Practice Information

Thank you for your interest in Kashi Health's genetic testing services.

Our genetic tests require guidance from a licensed healthcare provider. You may find a qualified provider from our list of approved professionals in the link below, or you may email your provider directly requesting that they contact us to request a genetic test. We wish you the best in your pursuit of healthy living.

1-877-879-1815

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by the production of auto-antibodies (such as anti-nuclear antibodies).

Patients may present with a diverse array of different clinical manifestations including skin, joint, hematologic, neurologic, renal and other organ involvement. SLE is predominantly a female disease, affecting females and males in a ratio of 9:1. Onset in women is usually between puberty and menopause, while onset outside this range is less common. The exact etiology of SLE is unknown, though it is thought to have a genetic component as well as environmental and hormonal components.

Clinical Utility:

The genetic component of SLE is supported by twin and family studies. Population studies have revealed that susceptibility to SLE is associated with HLA DRB1*03:01. Individuals homozygous for DRB1*03:01 or compound heterozygous for DRB1*03:01 and DRB1*15:01 carry the highest risk.

Genetic testing for SLE has significant clinical relevance in supporting efforts to more fully characterize the etiology and pathway of development of SLE. This may lead to improved diagnostic and prognostic tools.

Method:

Kashi Clinical Laboratories utilizes a combination of PCR-SSO (polymerase chain reaction sequence specific oligonucleotide typing) and SBT (sequence based typing) for testing.

Kashi's in-house laboratory and experienced health professionals ensure that customer service is personal, timely, and tailored to every patient's needs.

What is the Next Step? 

Make Kashi Health's Genetic Testing part of your patient's treatment plan today. 

Questions? Please contact our customer service team at 877-879-1815 or 503-206-4989 or by email at This email address is being protected from spambots. You need JavaScript enabled to view it. . We are available Monday through Friday, from 8:00 AM - 5:00 PM, Pacific Time.

 References
  1. Barcellos LF et al. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet. 2009; 5:e1000696.
  2. Danchenko N et al. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006; 15:308.
  3. Galeazzi M et al. Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations. European Concerted Action on the Immunogenetics of SLE. J Rheumatol. 2000; 27:135.
  4. International MHC and Autoimmunity Genetics Network, Rioux JD et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A. 2009; 106:18680.